The main findings of this study are that (1) restraint stress-induced anxiety-like behavior can be prevented by either acute selective FAAH or MAGL, but not by dual FAAH/MAGL, inhibition, (2) acute MAGL inhibition decreases novelty-induced anxiety and can reverse foot shock-induced anxiety-like behavior, (3) dual FAAH/MAGL, but not FAAH or MAGL, inhibition decreases body temperature and increases anxiety-like behavior and (4) none of the inhibitors impaired cognitive functions at doses relevant for anxiety-like behavior. The gene discussed is MGLL; the disease is Anxiety.