We found that out of a total of 21 TSSs that were upregulated in UCa or CDa vs. control, 66% (14/21) and 81% (17/21) were also upregulated in TNF-stimulated organoids and monocytes, respectively, at any time point; 47% (10) of TSS were upregulated in both stimulated organoids and monocytes (Fig. 2f and Supplementary Fig. 3b, c). Here, TNF is linked to congenital dyserythropoietic anemia.