In another investigation, serum starved apoptosis was co-related with increased MAO-A, caspase and MAPK expression in human neuroblastoma cells.5 MAO-A plays a critical role in staurosporine induced apoptotic cell death via altering caspase, Bcl-2 and p38/MAPK in SH-SY5Y human neuroblastoma cells.6 Clorgyline which is a MAO-A inhibitor can suppress the apoptotic effect of serum starvation in melanoma cells.7 Overall, MAO-A expression is reduced in breast cancer. This evidence concerns the gene MAOA and melanoma.