HDAC9 and neoplasm: Finally, a limitation of this study is that, similar to other pharmacological reagents, HDAC inhibitors such as Scriptaid have the potential to impact the function of multiple cell types found within the TME in ways that may inhibit39,52 or even support tumour progression.36,37 Thus, careful consideration of the dose, scheduling, and specific HDAC to be targeted should be optimised in therapeutic strategies using HDAC inhibitors alone or in combination with other drugs.