We tested the effect of Scriptaid on murine melanoma (B16F10) growth and CAF abundance in vivo using reporter mice that have fibroblasts genetically marked (SMA-DsRed:Col1-GFP mice).27,28 In this model, i.p. administration of Scriptaid inhibited tumour growth by ~twofold at the end of the experiment and diminished SMA+/Col1+ CAFs indicated by a clear reduction in DsRed/GFP signals on fresh cryosections (Fig. 5a, b). The gene discussed is SMN1; the disease is melanoma.