Way and colleagues trained a machine learning method to predict NF1 protein content, Bhoj et al. utilised a RASopathy sequencing panel in tandem with clinical examination to assess the presence of RASopathies, and Gosline et al. assembled the first public database of exome sequencing, RNA-seq and SNP array data for cNF.61–63 By integrating approaches such as these into cNF research, the field may be able to build upon prior studies to identify more accurate genotype–phenotype associations. The gene discussed is NPHS1; the disease is RASopathy.