NPHS1 and cancer: Epigenetic regulatory mechanisms are also thought to be involved in the development of other NF1-linked tumours; these or other epigenetic mechanisms may also be dysregulated in cNF.74,75 While many large-scale resources exist for exploring the mutational landscape of malignant tumours (e.g., TCGA, cBioPortal, Project GENIE), there are limited genomic explorations of neurofibromas.