NF1 and RASopathy: Recent efforts using machine learning approaches, targeted sequencing panels for genes involved in RASopathies (diseases that are a consequence of Ras pathway dysregulation, such as NF1), and open access data resources are attempting to address these challenges.61–63 Specifically, these approaches are leveraging recent technological advances to assess NF1 loss-of-function and the relationship between germline or somatic NF1 mutations with the resulting phenotype.