An example of such a target is vascular endothelial growth factor (VEGF), an angiogenic signalling molecule that is highly expressed in cNFs and other NF1-linked tumours.119,120 A trial investigated the potential for VEGF as a viable target by directly injecting the VEGF inhibitor ranibizumab into cNFs.121 The primary outcomes of the trial were changes to cNF volume and interstitial pressure. Here, NF1 is linked to neoplasm.