Although there are currently no studies comparing gene/miRNA expression or methylation in cNF with unaffected normal tissue such as myelinated nerve tissue, several studies have compared methylation and RNA/miRNA expression patterns in cNF to other NF-related tumour types.72,73 These studies identified significant differences between cNFs, pNFs and MPNSTs, with respect to their DNA methylation, miRNA and gene expression profiles. This evidence concerns the gene NPHS1 and neoplasm.