VEGFA and neoplasm: An example of such a target is vascular endothelial growth factor (VEGF), an angiogenic signalling molecule that is highly expressed in cNFs and other NF1-linked tumours.119,120 A trial investigated the potential for VEGF as a viable target by directly injecting the VEGF inhibitor ranibizumab into cNFs.121 The primary outcomes of the trial were changes to cNF volume and interstitial pressure.