Among these, global levels of PTPRM, MCAM, DEFA1B, CFHR1, BST1, PF4, VTN, and C7 were significantly higher in the PCa group than in the BPH group, and LSAMP, TFRC, KLKB1, ABI3BP, GPX3, AHSG, GSN, B2M, FETUB, LRG1, and C1QC were significantly lower in the PCa than in the BPH. This evidence concerns the gene KLKB1 and posterior cortical atrophy.