Additionally, the increase in global levels of proteins AZGP1, and PROS1 were significantly different between PCa and BPH (p = 0.0003 and p = 2.33E-06, respectively), however it should be noted that AZGP1 and PROS1 were not particularly over-expressed in PCa with respect to the reference sample (both yielded log2H/L values around 0.35, or a 1.25-fold increase), making these proteins less ideal as potential candidates for diagnostic biomarkers. Here, AZGP1 is linked to benign prostatic hyperplasia.