ADAMTSL4, SSC5D, VCAM1, and IGFBP7, to highlight a few, presented similar cases in which different M-LAC fractions showed log2H/L ratios in opposing directions – a trend that would not have been observed without glycosylation-based fractionation – but ultimately resulted in indistinguishable patterns between PCa and BPH groups. Here, SSC5D is linked to benign prostatic hyperplasia.