There are 252 cancer-associated S768 mutations at EGFR (Table 2, ProKinO), and two SNPs that result in the substitution of isoleucine for serine at position 768 (rs397517108 and rs121913465, Table 2, neXtProt) are considered pathogenic or likely pathogenic in lung cancer, according to ClinVar20. The gene discussed is EGFR; the disease is lung carcinoma.