ANGPTL3 and type 2 diabetes mellitus: In our study, we therefore explored the changes of ANGPTL3 and ANGPTL4 circulating levels and their mRNA expression in subcutaneous adipose tissue (SAT) of obese subjects with and without type 2 diabetes mellitus (T2DM) as well as chronically malnourished individuals with anorexia nervosa (AN) or short bowel syndrome (SBS) as models of severe malnutrition of different etiology.