In our study, we therefore explored the changes of ANGPTL3 and ANGPTL4 circulating levels and their mRNA expression in subcutaneous adipose tissue (SAT) of obese subjects with and without type 2 diabetes mellitus (T2DM) as well as chronically malnourished individuals with anorexia nervosa (AN) or short bowel syndrome (SBS) as models of severe malnutrition of different etiology. The gene discussed is ANGPTL3; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.