VAMP5 and Hirschsprung disease: Shin JG et al. suggested that two single nucleotide polymorphisms (SNP, rs10206961 and rs1254900) of VAMP5 were the potential risk locus in TCA progression by using 187 Korean HSCR patients and 283 unaffected controls (P=0.006 for rs10206961, P=8.03×10-5 for rs1254900), we also included SNP rs14242 in VAMP5 with suggestive significance to HSCR (P=0.04) for further replication [12].