Unilateral brain damage recovery following stroke largely depends on a reshaping of the interhemispheric balance between the CSE and SMI of the affected and unaffected hemispheres mediated by transcallosal inhibition [65–68], and by adaptive changes in FPEC within PF, SMA, and CP regions, including a hyperconnectivity among SMA, CP, and O regions [69], so as to vicariate the loss of neural pathways and to restore the impaired function. The gene discussed is CP; the disease is stroke disorder.