To clarify the importance of these miRNAs in carcinogenesis, we examined the association between the expression levels of these organ-specific miRNAs and the Warburg-effect-related genes, i.e., PTBP1 and PKM2. As shown in Figure 4A, brain-specific MIR137 was downregulated in GBM cell lines compared with its expression in the normal brain tissue; and mRNA expression levels of PTBP1 and PKM2 were upregulated. Here, PKM is linked to glioblastoma.