GAS1 and pancreatic adenocarcinoma: Upregulation of SMO and Hh coreceptors [growth arrest-specific protein 1 (GAS1), brother of CDO (BOC), and cell adhesion molecule-related/down-regulated by oncogenes (CDON)] has been, for example, observed in cancer-associated fibroblasts derived from pancreatic adenocarcinomas [50,51].