Thus, antiangiogenic drugs that mainly target the VEGF/VEGF receptor signaling pathway have been administered in combination with chemotherapeutic drugs in many types of cancers; however, although antiangiogenic drugs were believed to be less toxic than other cytotoxic drugs, recent studies have shown that they might also induce severe side effects, such as lethal hemoptysis [7,8] and intestinal perforations [9,10]. This evidence concerns the gene VEGFA and cancer.