In pregnant women with overweight or obesity, supplementation with n-3 PUFA (DHA: 1200 mg/day; EPA: 1200 mg/day) from week 16 gestation to delivery lowered the expression of inflammatory cytokines (IL6, IL8, TNFα and TLR4 mRNA) in adipose and placental tissue compared with the control group (p < 0.001), as well as decreasing C-reactive protein at time of delivery [71]. This evidence concerns the gene CXCL8 and obesity due to melanocortin 4 receptor deficiency.