The number of individuals with T2DM as well as microvascular complications (retinopathy, nephropathy or diabetic neuropathy) or other diseases related to metabolic syndrome such as hypertension, dyslipidemia, and cardiovascular diseases was small and no statistically significant difference was found in relation to polymorphisms of the ACE and MTHFR genes. Here, MTHFR is linked to diabetic neuropathy.