Case-case analyses of rs1021737 using the NSHDS data yielded a similar association to CRC risk by KRAS and BRAF mutation status as the case-control analyses, i.e., CRC cases with variant rs1021737 genotype were more likely to be KRAS-mutant, and less likely to be BRAF-mutant compared to KRAS/BRAF wild type (P = 0.04, Table 3). The gene discussed is BRAF; the disease is colorectal carcinoma.