Mutated BRAF is also more prevalent in older patients, in tumors originating from serrated lesions, tumors with extensive hypermethylation of CpG islands in tumor suppressor gene promoters (i.e., the CpG island methylator phenotype (CIMP)), as well as tumors with microsatellite instability (MSI) caused by malfunctioning DNA mismatch repair [6, 10]. The gene discussed is BRAF; the disease is neoplasm.