UP446, a composition consisting primarily of baicalin from Scutellaria baicalensis Georgi and catechin from the heartwoods of Acacia catechu, has been previously shown to reduce the production of eicosanoids and leukotrienes through dual inhibition of COX and lipo-oxygenase (LOX) enzymes and to decrease mRNA and protein levels of IL-1β, IL-6, and TNF-α, suggesting a potential benefit of UP446 in alleviating symptoms of RA and support further assessment of this botanical composition in patients with RA [81]. The gene discussed is TNF; the disease is rheumatoid arthritis.