IDH2 and central nervous system cancer: In addition to the TERT promoter hotspot mutations, we identified a common single nucleotide polymorphism (SNP) (T349C) [32] across all types of gliomas we investigated (Figure 1(d)): IDH-mutant astrocytic tumors (6 out of the 11 tumors: 54.5%), oligodendroglial tumors (3 out of the 10 tumors: 30.0%), GBM (10 out of the 11 tumors: 90.9%), and IDH-wildtype diffuse astrocytomas (3 out of the 9 tumors: 33.3%).