Our unexpected findings suggest that a specific TERT-targeting therapy might be a promising therapeutic strategy against all types of gliomas by directly targeting tumor cells with an indirect antiangiogenic effect on tumor vasculature like the antiangiogenic agent bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF) ligands [46], but the additional studies are essential to demonstrate that the presence of TERT protein actually implies more aggressive biology for the recommendation of treatment based on TERT immunohistochemistry. The gene discussed is VEGFA; the disease is glioma.