TERT and central nervous system cancer: Our unexpected findings suggest that a specific TERT-targeting therapy might be a promising therapeutic strategy against all types of gliomas by directly targeting tumor cells with an indirect antiangiogenic effect on tumor vasculature like the antiangiogenic agent bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF) ligands [46], but the additional studies are essential to demonstrate that the presence of TERT protein actually implies more aggressive biology for the recommendation of treatment based on TERT immunohistochemistry.