Histologically, the diagnosis of “fibrosarcoma” was applied only to cases displaying one or more of the following characteristics [7, 8]: (1) hyperchromatic spindled cells depicting no more than moderate pleomorphism, (2) a fascicular “herringbone” pattern, (3) a variable degree of interstitial collagen, (4) no morphologic features of myxofibrosarcoma, low-grade fibromyxoid sarcoma, sclerosing epithelioid fibrosarcoma, or fibrosarcoma arising in dermatofibrosarcoma protuberans, and (5) no expression of any markers other than vimentin or very minimal smooth muscle actin. The gene discussed is VIM; the disease is fibrosarcoma.