In this case, the cooperation occurred via blocking Hedgehog pathway signalling, which normally acts to restrict Delta/Serrate-Notch signalling during eye development. mir-7 reduced translation of the Hedgehog receptor mRNA, ihog (interference hedgehog), whereas Notch signalling blocked transcription of the coreceptor gene, boi (brother of ihog), thereby leading to reduced Hedgehog signalling and enhancing Delta-Notch-driven tumour growth and invasion. The gene discussed is CDON; the disease is neoplasm.