CDON and familial pancreatic carcinoma: These studies may provide insights into some forms of human cancer, where the mir-7 ortholog is overexpressed and oncogenic, such as lung and skin cancers [240], or the Ihog orthologs (BOC and CDO) are downregulated or have a tumour-suppressor functions, such as in pancreatic cancer [241] or rhabdomyosarcoma [242].