INSR and neoplasm: Genes upregulated included those encoding the Insulin Receptor (InR), Rap1 (a Ras-related protein), and Dilp8 (insulin-related peptide), which are likely to affect tumour growth by promoting cell proliferation and in the case of Dilp8 by delaying pupariation through downregulation of Ecdysone production in the prothoracic gland.