When cell polarity genes (scrib, dlg, and lgl) are mutated or knocked down in a clonal context, aberrant mitotic spindle orientation, cell polarity impairment, ectopic cell proliferation, and aberrant differentiation occur, but, despite this, malignant tumours do not form, and the mutant tissue is mostly eliminated by JNK-mediated cell death [23, 90, 91, 136, 141, 182]. This evidence concerns the gene SCRIB and cancer.