This mechanism might be important in mammalian cancer, since JAGGED1  (mammalian ortholog of Delta/Serrate) is regulated by the miR-8 orthologs, miR-200c, and miR-141, in colorectal cancer cell lines [119], and reduced miR-200 expression is associated with coupregulation of JAGGED1 and ZEB1 proteins in pancreatic and basal-type breast cancer cell lines [239]. The gene discussed is JAG1; the disease is colorectal cancer.