Additionally, PI3K or Akt overexpression has been previously shown to cooperate with Delta overexpression in the eye epithelial tissue to induce an overgrown invasive phenotype, which might be relevant to human cancer, particularly T cell acute lymphoblastic leukaemia, where Notch and Akt pathway activation often occurs [117, 237]. This evidence concerns the gene AKT1 and T-cell acute lymphoblastic leukemia.