A recent study has also revealed cooperative tumorigenesis in glial tumour growth and invasion between RasV12 and overexpression of pico (a MRL family gene), chickadee (profilin, encoding an actin-cytoskeletal regulator) or Mal (encoding a cofactor of Serum Response Factor (SRF)) [107], suggesting that SRF signalling might be a novel pathway to investigate in human glioblastomas. This evidence concerns the gene SRF and glioblastoma.