ENAH and neoplasm: Conversely, hyperactivation of the Slit-Robo-Ena pathway in scrib mutant or wild-type cells results in a hyperextrusive phenotype, with the apically (lumenally) extruded cells forming overgrown tumours, which might occur by the peripodial membrane epithelium preventing access of the innate cellular immune system cells to the tumour [45, 46].