NFKB1 and injury: Also, it has been shown that inhibition of NF-κB by geraniin, a natural compound with anti-inflammatory effect, [51] or penehyclidine hydrochloride, a selective anticholinergic agent, [52] alleviated lipopolysaccharide- (LPS-) induced acute lung injury in mice by blocking the production of proinflammatory cytokine.