TMC1 and hearing loss disorder: In 2015, Chen et al. investigated the nonsyndromic sensorineural hearing loss using targeted next-generation sequencing technique in the Uyghur families, and some novel pathogenic mutations were identified in four probands including the p.L416R/p.A438T compound heterozygous mutations in TMC1, homozygous p.V1880E mutation in MYO7A, c.1238delT frame-shifting deletion in PCDH15, and c.9690+1G>A splice site mutation in MYO15A. Besides, rare mutations have been identified in the hearing loss that is rarely diagnosed in the Uyghur minority [6].