In addition to the findings of these immune-regulatory genes, many other top associations have been implicated in obesity (AEBP2) (FDR < 0.10), calcium signaling (CAPNS1), insulin signaling (INSR, PTPRN2, RPTOR), and vasodilation (VASP). This evidence concerns the gene CAPNS1 and obesity due to melanocortin 4 receptor deficiency.