Maple et al. reported that increased methylation of specific CpGs in the CPT1B promoter was correlated with decreased CPT1B transcripts in the skeletal muscle after lipid oversupply in severe obesity, which resulted in obese individual’s incapacity to increase fat oxidation, contributing to metabolic inflexibility [39]. This evidence concerns the gene CPT1B and obesity due to melanocortin 4 receptor deficiency.