Here, we reported that NLRP3 and caspase-1 were required for the activation of IL-1β in a murine model of ConA-induced AIH, and mice deficient in NLRP3 or caspase-1 (NLRP3−/− or caspase-1−/−) were protected from hepatitis. This evidence concerns the gene CASP1 and hepatitis A virus infection.