HLA-B and infection: For example, peptide MVTLYLGVM found in serotype 1, belonging to P1 series (RRDHF = 0.13; HLA-B*35:01 binding IC50 = 260.49 nM) demonstrated single amino acid variation with peptide IVTLYLGVM in serotype 2, belonging to P2 series (RRDHF = 3.16; HLA binding IC50 for same allele = 2,719.9 nM); thereby rendering hosts with HLA-B*35:01 vulnerable to DHF in case of secondary infection with serotype 2 following primary infection with serotype 1 (Table 4).