The results revealed that GAPLINC knock-down significantly reduced IL-6 (P < 0.01), IL-8 (P < 0.05), and MMP-9 (P < 0.05) production of RA-FLSs when compared to the NC-siRNA control group (Figure S1 in Supplementary Material). This evidence concerns the gene MMP9 and rheumatoid arthritis.