TLR2 can be activated by glycosylphosphatidylinositols (GPIs) presented on some protozoa and participates in the host defense against parasite infection (Oliveira-Nascimento et al., 2012), including Toxoplasma gondii and Trypanosoma cruzi (Campos et al., 2001; Debierre-Grockiego et al., 2007) The expression of TLR2 has been confirmed in various cells, such as endothelial cells, epithelial cells, and macrophages (Flo et al., 2001; Yadav and Schorey, 2006; Brzezińska-Błaszczyk and Wierzbicki, 2010). This evidence concerns the gene TLR2 and parasitic infectious disease.