Furthermore, DRF2 (encoding mDia3 protein) suppression was correlated with primary ovarian failure (Wynshaw-Boris et al., 1997; Bione et al., 1998; Tominaga et al., 2002), while in DRF3 (encoding mDia2 protein) knockdown cells and mice, severe defects in erythrocyte maturation and enucleation were seen (Ji et al., 2008; Watanabe et al., 2013; Mei et al., 2016). Here, DIAPH2 is linked to primary ovarian failure.