Whereas, mDia2 suppression drove alternative modes of tumor cell motility in cervical, ovarian, breast, and prostate cancers, and hepatocarcinoma models (Eisenmann et al., 2007a; Di Vizio et al., 2009; Hager et al., 2012; Wyse et al., 2012; Pettee et al., 2014), glioblastoma cells in vitro and ex vivo spheroid-rat brain slice models showed IMM-induced mDia2 agonism more effectively blocked glioblastoma migration and invasion than antagonism, with no toxicity in rat brain slice explants (Arden et al., 2015). Here, DIAPH3 is linked to prostate cancer.