Allosteric P2X4 receptor activation also improved the lifespan of superoxide dismutase 1 (SOD1) transgenic mice harboring the G92A mutation (Gly-93 to Ala)—a conventional animal model of ALS—by 10% and increased the number of ventral horn MNs in the spinal cord (Andries et al., 2007). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.