Taking into account that P2Y6 receptor selective inhibition by MRS2578 is able to prevent microglial phagoptosis in a mixed neuronal/glial culture in inflammatory conditions (Neher et al., 2014), P2Y6 receptor antagonism seems to be a promising tool to attenuate neuronal death in PD by preventing lesion worsening due to phagocytosis of viable neurons. The gene discussed is P2RY6; the disease is Parkinson disease.