AKT1 and neoplasm: Among TORKIs, PP242 induces mitophagy followed by cell death in ERas-treated cells (Gordeev et al., 2015), inhibits adult T cell leukemia proliferation and AKT phosphorylation on serine 473, in vitro, and reduces tumor growth in a leukemia xenograft mouse model (Kawata et al., 2018).