Additionally, in light of recent data supporting a role of mTORC2 in the induction of NF-κB(p65) phosphorylation as a chemotherapy resistance mechanism in GBM (Tanaka et al., 2011), we evaluated weather PI3K, mTORC1 or mTORC2 pharmacological inhibition could modulate NF-κB(p65) phosphorylation. This evidence concerns the gene NFKB1 and glioblastoma.