This analysis revealed that AKT expression and phosphorylation increases with the histological grade and correlates with a worse overall survival in GBMs, while RICTOR is overexpressed in grade I and II astrocytomas and a shift to a nuclear localization has been demonstrated in GBMs (Alvarenga et al., 2017). The gene discussed is AKT1; the disease is astrocytoma (excluding glioblastoma).