GLS and glioblastoma: Moreover, the administration of PP242 in a GBM cell line overexpressing EGFRvIII, causes cytoskeletal changes that affect cell motility (Chantaravisoot et al., 2015), while in GBM-bearing mice, the combined administration of PP242 and a glutaminase inhibitor induces cell death and reduces tumor growth (Tanaka et al., 2015).