Consistent with the previous findings in the study of MLL-AF9 AML15, L-GMP of MLL-AF6 AML cells were markedly enriched for leukemia-initiating potential compared to whole BM (L-GMP vs whole BM; 1:6.4 vs 1:531, p < 0.001) (Fig. 5b and Supplementary Fig. 5a). Here, KMT2A is linked to leukemia.