We investigated the expression of ten circadian clock genes (SHARP2, BMAL1, CLOCK, CRY1, CSNK1E, PER1, PER2, PER3, CUL1, and NR1D) in AML patients, comparing MLL-AF6 to other MLLr or non-MLLr AML, none of which exhibited aberrant expression (Supplementary Fig. 6d). Here, CLOCK is linked to acute myeloid leukemia.