In human AML cell lines, consistent with our findings in the gene expression profiles from the multiple AML cohorts, SHARP1 mRNA was expressed highly in ML-2, CTS and SHI-1 cells, all of which harbor t(6;11)(q27;q23), whereas it was undetectable in MOLM-14, MV4-11 and Kasumi-1, which harbor t(9;11)(p22;q23), t(4;11)(q21;q23), and t(8;21)(q22;q22), respectively (Fig. 2a). Here, BHLHE41 is linked to acute myeloid leukemia.