KMT2A and acute myeloid leukemia: To identify specific targets of MLL-AF6, we further interrogated gene expression profiles of adult AML patients, comparing MLL-AF6 (14 cases) to the other subtypes of MLLr-AML (42 cases) and found 581 genes significantly upregulated in MLL-AF6 AML patients (Log2 fold > 0.5, p < 0.05).