The downregulated genes were associated with cell cycle, TGF-β signaling, FoxO signaling, HIF-1 signaling, and cancer (CDKN1B, FLT3, PDK1, FOXO1, BCL2, ERG) (Supplementary Fig. 6c), suggesting potential positive regulation of these pathways by SHARP1 to maintain MLL-AF6 AML activity. Here, KMT2A is linked to acute myeloid leukemia.