Neither SEA nor SWAP stimulated IFNγ production by either cell populations, but these antigenic preparations did induce IL-10 production by PBMC cultures, and this ability was decreased in Treg-depleted cultures from most individuals (Figure 4A and B), albeit not significantly in regard to SEA, suggesting that during human schistosomiasis Treg cells are a main source of immunoregulatory IL-10. This evidence concerns the gene IL10 and schistosomiasis.