Overexpression of CMTM5 and CMTM3, which are two members of CMTM family, inhibited tumour progression both in vitro and In vivo.11, 20 The two studies indicated that miR‐10b and CMTM5 could also be useful biomarkers for HCC metastasis, which can be further investigated in the following studies. This evidence concerns the gene CMTM3 and neoplasm.