Multiple researches showed high level of miR‐10b‐3p expression was detected in HCC tissues and cell lines,5, 15, 16 whereas CMTM expression was down‐regulated in liver cancer tissues compared with the adjacent non‐tumour tissues.11, 17 Similarly, our results also demonstrated high expression of miR‐10b‐3p and low expression of CMTM5 in HCC cell lines. The gene discussed is CMTM5; the disease is hepatocellular carcinoma.