15 Other researches implied CSMD1 and CADM1 could also be regulated by miR‐10b.5, 18 Most of these genes acted as tumour suppressors, so we assumed that miR‐10b could suppress certain anticancer factors including CMTM5. In our study, we proved that CMTM5 was a target gene of miR‐10b‐3p in HepG2 cell line. This evidence concerns the gene CADM1 and neoplasm.