Upregulated genes identified by genome-wide mRNA screening fell into 31 gene sets; approximately 19 of these sets were associated with immune signaling: targeting of the immune response to specific cells (NKT pathway), inflammation (NF-κB, IL1R, IL6, P38MAPK, INFLAM, GSK3 and TH1/TH2 pathway), apoptosis (NF-κB, TNFR2, P38MAPK, TID, 41BB, CASPASE and FAS pathway), autoimmune diseases (NF-κB, TOB1 and FAS pathway), migration (MCALPAIN pathway) and antigen-specific immune response (TOLL, TNFR2, HIVNEF, DC and IL2R pathway) (Garbett et al. 2008). The gene discussed is FAS; the disease is autoimmune disease.