VDAC1 and Alzheimer disease: The two mitochondrial proteins whose levels were quantitated in hippocampal extracts were VDAC-1 (Fig. 8a), a voltage-dependent anion channel differentially expressed in the brain of AD mouse models32, and hexokinase type 1 (HXKI) (Fig. 8b), which is differentially expressed in AD patients33 and Tg2576 mice32.