DHODH and postaxial acrofacial dysostosis: Further, rs12599952 regulated the expression of DHODH in several tissues (lowest P = 1.6 × 10−11, FDR = 0.0003 for tibial artery), a gene responsible for Miller syndrome including severe micrognathia, cleft lip and/or palate, hypoplasia, eyelid coloboma, and accessory nipples and several other developmental abnormalities.