A complete biodistribution study of [225Ac]hu11B6 was performed in a genetically modified mouse model (Hi-Myc x pb_KLK2) that has prostate specific expression of human hK2 (pb_KLK2) and spontaneous development of prostate adenocarcinoma (Hi-Myc) at 20–30 weeks of age (Fig. 3a). The gene discussed is HK2; the disease is prostate adenocarcinoma.