Mouse null mutation of the L3MBTL3 (MBT-1−/−) gene was reported to impair the maturation of hematopoietic system, reduce the expression of genomic imprinted CDK inhibitor p57Kip2 gene, and cause anemia and late embryonic lethality around E17.5-E19.547. Here, L3MBTL3 is linked to anemia.