Mutation of ROQUIN (Rc3h1) in Roquinsan/san mice, another model of lupus, leads to reduced decay of IFN-γ mRNA, resulting in increased IFN-γ signaling and accumulation of Tfh cells, culminating in an increase in GC B cells and autoantibodies7. This evidence concerns the gene IFNG and systemic lupus erythematosus.