ZNF146 and cancer: The methylation level in the cancer genome was decreased in characteristic epigenomic segments, including in active chromatic genome regions that were annotated with proximal promoters (C2), a transcribed state at the 5′ and 3′ ends of genes showing both promoter and enhancer signatures (C3), enhancers (C7), and a state associated with zinc finger protein genes (C8), and in inactive regions annotated with heterochromatin (C9), repressed Polycomb (C13 and C14) and quiescent/low (C15) (Fig. 1b, c, Supplementary Table 3).