We found nine significant associations for imputed PTVs (BY-adjusted p < 0.05, Supplementary Data 3) including rs74315329 in MYOC and glaucoma (MAF = 0.0012, p = 1.8 × 10−30, OR = 4.71, 95% CI: 3.61–6.14)53, a well-known risk variant for glaucoma54, and D2HGDH and asthma (MAF = 0.445, p = 1.6 × 10−12, OR = 0.95, 95% CI: 0.94–0.96) and hayfever (coded hayfever/allergic rhinitis) (p = 8.4 × 10−9, OR = 0.94, 95% CI: 0.92–0.96). This evidence concerns the gene MYOC and asthma.