rs180177132 in PALB2 was associated with a family history of breast cancer (MAF = 0.037%, p = 2.5 × 10−8; OR = 2.14, 95% CI: 1.64–2.79) as well as breast cancer diagnosis (p = 9.0 × 10−12; OR = 4.25, 95% CI: 2.80–6.43) and FUT2 was associated with family history of high blood pressure (MAF = 49.1%, p = 1.3 × 10−7; OR = 1.03, 95% CI: 1.02–1.04), hypertension diagnosis (p = 5.7 × 10−13; OR = 1.04, 95% CI: 1.03–1.05), and essential hypertension (p = 5.2 × 10−8, OR = 1.04, 95% CI: 1.02–1.05). This evidence concerns the gene PALB2 and essential hypertension.