VKORC1 and myxedema: We identified additional protective associations between PTVs in IFIH1 and hypothyroidism (labeled as hypothyroidism/myxedema) (MAF = 1.5%, p = 1.7 × 10−6, OR = 0.80, 95% CI: 0.73–0.88) and VKORC1 and hypertension (MAF = 25.3%, p = 1.4 × 10−6, OR = 0.97, 95% CI: 0.96–0.98).