For instance, the gain-of-function PTV rs328 in LPL (MAF = 10.1%) that we find to be associated with decreased risk for high cholesterol (p = 3.9 × 10−15, OR = 0.90, 95% CI: 0.88–0.93) and angina (p = 1.3 × 10−7, OR = 0.91, 95% CI: 0.87–0.94) has been associated with coronary artery disease, lipid metabolism, and lower triglyceride levels17,38,39. Here, LPL is linked to angina pectoris.