The immune cells that express membrane ST2 (ST2L), including tissue regulatory T cells (Tregs) and group 2 innate lymphoid cells (ILC2s), especially, mast cells, which are major targets of IL-33 and induce the production of different types of cytokines that play crucial roles in the exacerbation of allergic diseases and inflammation17. The gene discussed is IL33; the disease is allergic disease.