We clustered the TSGs into distinct functional classes, and, from that analysis, we showed that in vitro infection of the NCI-N87 gastric cells by H. pylori and EBV was associated with transcriptional repression of a number of cell cycle genes (APC, BRCA1, CDKN2A, FHIT, NEUROG1, PTEN, RUNX3, TP73, and VHL), genes involved in apoptosis (BRCA1, CDKN2A, MGMT, PTEN, RUNX3, TP73, and VHL), and genes involved in DNA damage repair (APC, BRCA1, MGMT, and TP73) (Fig. 5B, C, and D) (Table S2). Here, RUNX3 is linked to infection.