Consistent with the presence of S. aureus in the PJI cohort bone, mRNA levels of a number of chemokines stimulated by infection, including CCL5, CXCL9, CXCL10, and CXCL11 (Fig. 2H), were upregulated in bone specimens from the infected acetabulum site of PJI patients but not the uninfected iliac wing. The gene discussed is CXCL11; the disease is juvenile polyposis syndrome.