The unadjusted analysis showed a borderline significant association between McCb and increased susceptibility to severe malaria overall (OR 1.17; 1.00–1.25; p=0.056, Supplementary file 1D), and significant associations with increased risk of cerebral malaria (OR 1.21; 1.05–1.39; p=0.008) and death (OR 1.34; 1.00–1.77; p=0.046, Supplementary file 1D). The gene discussed is MCCC1; the disease is cerebral malaria.