The sortilin C-terminal antibody exhibited only cellular but not plaque-like labeling in sections across the entire rostrocaudal dimension of the cerebrum from the 14-month-old APP/PS1 mice (Fig. 3a, showing an image of a coronal section at the striatum level covering both hemispheres), 8-month-old 5×FAD mice (Fig. 3d, coronal section at the mid-hippocampal level covering one hemisphere), and 22-month-old 3×Tg-AD mice (Fig. 3g, sagittal cerebral section passing the middle part of hippocampus). This evidence concerns the gene PSEN1 and Alzheimer disease.