A growing number of studies show that genetic variations among members of this family, including sortilin-related receptor L1 (SORL1, also known as SORLA, SORLA1, or LR11) [52–58], sortilin-related Vps10p domain-containing receptor 1 (SORCS1) [59], and sortilin [60], are related to the risk of developing AD. This evidence concerns the gene SORT1 and Alzheimer disease.