Abbreviations: WBC – White blood cell; BM – Bone marrow; FAB – The French-American-British classification of AML; MRC – Medical Research Council cytogenetic classification; MDS – Myelodysplastic syndrome; MK – Monosomal Karyotype; NPM1 – Nucleophosmin 1; FLT3-ITD – Fms related tyrosine kinase 3 - internal tandem duplication; FLT3-TKD – Fms related tyrosine kinase 3 - tyrosine kinase domain; BCR-ABL – Break point cluster region - Abelson murine leukemia viral oncogene homolog 1; RAR – Retinoic acid receptor. Here, NPM1 is linked to acute myeloid leukemia.