WEE1 and nervous system disorder: In addition, there were several patents about application of these marine-derived protein kinase inhibitors or their derivatives, including lestaurtinib for the treatment of neurodegenerative diseases [63] and the treatment or prevention of pain disorders [64], enzastaurin for the treatment of neurological diseases [65], and bis-N-substituted derivatives of staurosporine for the treatment of neurological disorders [66, 67].