CKD chronic kidney disease, PEEP positive end-expiratory pressure; SOFA sequential organ failure assessment, MV mechanical ventilation, MODS multiple organ dysfunction score, GFR glomerular filtration rate; LODS logistic organ dysfunction score, UO urine output, RRT renal replacement therapy, KDIGO Kidney Disease Improving Global Outcomes; RIFLE Risk, Injury, Failure, Loss of kidney function, End-stage kidney disease, TAK-242 a small-molecule inhibitor of Toll-like receptor-4-mediated, ARDS acute respiratory distress syndrome, IABP intraaortic balloon pump, Cr creatinine. This evidence concerns the gene TLR4 and chronic kidney disease.